Publications

Selected Publications

2021

Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.

Roffman JL, Sipahi ED, Dowling KF, Hughes DE, Hopkinson CE, Lee H, Eryilmaz H, Cohen LS, Gilman J, Doyle AE, Dunn EC.

PLoS One. 2021 Apr 28;16(4):e0250235. doi: 10.1371/journal.pone.0250235. eCollection 2021.

PMID: 33909652

Altered temporal, but intact spatial, features of transient network dynamics in psychosis.

Wang D, Peng X, Pelletier-Baldelli A, Orlov N, Farabaugh A, Nasr S, Eryilmaz H, Fava M, Holmes AJ, Roffman JL, Liu H, Holt DJ.

Mol Psychiatry. 2021 Jan 18. doi: 10.1038/s41380-020-00983-1. Online ahead of print.

PMID: 33462330

2020

In vivo human brain expression of histone deacetylases in bipolar disorder.

Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM.

Transl Psychiatry. 2020 Jul 8;10(1):224. doi: 10.1038/s41398-020-00911-5.

PMID: 32641695

Working memory load-dependent changes in cortical network connectivity estimated by machine learning.

Eryilmaz H, Dowling KF, Hughes DE, Rodriguez-Thompson A, Tanner A, Huntington C, Coon WG, Roffman JL.

Neuroimage. 2020 Aug 15;217:116895. doi: 10.1016/j.neuroimage.2020.116895. Epub 2020 May 1.

PMID: 32360929

2019

Endophenotype Research in Psychiatry-The Grasshopper Grows Up.

Roffman JL.

JAMA Psychiatry. 2019 Dec 1;76(12):1230-1231. doi: 10.1001/jamapsychiatry.2019.2194.

PMID: 31596450

Reaffirming Core Scientific Values in Psychiatry Research.

Roffman JL.

Harv Rev Psychiatry. 2019 Sep/Oct;27(5):275-278. doi: 10.1097/HRP.0000000000000231.

PMID: 31490185

Neuroepigenetic signatures of age and sex in the living human brain.

Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM.

Nat Commun. 2019 Jul 3;10(1):2945. doi: 10.1038/s41467-019-11031-0.

PMID: 31270332

B Vitamin Supplements in First-Episode Psychosis: Some Neurodevelopmental and Physiologic Context.

Roffman JL.

Biol Psychiatry. 2019 Jul 1;86(1):4-6. doi: 10.1016/j.biopsych.2019.05.004.

PMID: 31221246

Functional connectomics of affective and psychotic pathology.

Baker JT, Dillon DG, Patrick LM, Roffman JL, Brady RO Jr, Pizzagalli DA, Öngür D, Holmes AJ.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9050-9059. doi: 10.1073/pnas.1820780116. Epub 2019 Apr 15.

PMID: 30988201

Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders.

Hart KL, Brown HE, Roffman JL, Perlis RH.

Neuropsychology. 2019 Mar;33(3):417-424. doi: 10.1037/neu0000506. Epub 2019 Jan 28.

PMID: 30688494

A New Era for the Harvard Review of Psychiatry.

Roffman JL.

Harv Rev Psychiatry. 2019 Jan/Feb;27(1):1-2. doi: 10.1097/HRP.0000000000000221.

PMID: 30614885

PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.

Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM.

J Clin Invest. 2019 Jan 2;129(1):364-372. doi: 10.1172/JCI123743. Epub 2018 Dec 10.

PMID: 30530989

2018

Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths.

Eryilmaz H, Dowling KF, Huntington FC, Rodriguez-Thompson A, Soare TW, Beard LM, Lee H, Blossom JC, Gollub RL, Susser E, Gur RC, Calkins ME, Gur RE, Satterthwaite TD, Roffman JL.

JAMA Psychiatry. 2018 Sep 1;75(9):918-928. doi: 10.1001/jamapsychiatry.2018.1381.

PMID: 29971329

Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders.

Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH.

NPJ Schizophr. 2018 May 28;4(1):9. doi: 10.1038/s41537-018-0050-z.

PMID: 29808011

Neuroprotective Effects of Prenatal Folic Acid Supplementation: Why Timing Matters.

Roffman JL.

JAMA Psychiatry. 2018 Jul 1;75(7):747-748. doi: 10.1001/jamapsychiatry.2018.0378.

PMID: 29801055

Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects.

Ellard KK, Zimmerman JP, Kaur N, Van Dijk KRA, Roffman JL, Nierenberg AA, Dougherty DD, Deckersbach T, Camprodon JA.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 May;3(5):473-484. doi: 10.1016/j.bpsc.2018.01.013. Epub 2018 Feb 7.

PMID: 29580768

The human cortex possesses a reconfigurable dynamic network architecture that is disrupted in psychosis.

Reinen JM, Chén OY, Hutchison RM, Yeo BTT, Anderson KM, Sabuncu MR, Öngür D, Roffman JL, Smoller JW, Baker JT, Holmes AJ.

Nat Commun. 2018 Mar 20;9(1):1157. doi: 10.1038/s41467-018-03462-y.

PMID: 29559638

S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.

Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT.

Neurotherapeutics. 2018 Jan;15(1):156-175. doi: 10.1007/s13311-017-0593-0.

PMID: 29340929

The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.

Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, Picchioni MM, Bramon E, Russo M, David AS, Mondelli V, Reinders AATS, Falcone MA, Hartmann AM, Konte B, Morris DW, Gill M, Corvin AP, Cahn W, Ho NF, Liu JJ, Keefe RSE, Gollub RL, Manoach DS, Calhoun VD, Schulz SC, Sponheim SR, Goff DC, Buka SL, Cherkerzian S, Thermenos HW, Kubicki M, Nestor PG, Dickie EW, Vassos E, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Seidman LJ, McCarley RW, Petryshen TL.

Schizophr Res. 2018 May;195:306-317. doi: 10.1016/j.schres.2017.09.024. Epub 2017 Oct 3.

PMID: 28982554

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.

Roffman JL, Petruzzi LJ, Tanner AS, Brown HE, Eryilmaz H, Ho NF, Giegold M, Silverstein NJ, Bottiglieri T, Manoach DS, Smoller JW, Henderson DC, Goff DC.

Mol Psychiatry. 2018 Feb;23(2):316-322. doi: 10.1038/mp.2017.41. Epub 2017 Mar 14.

PMID: 28289280

2017

A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults.

Cummings D, Dowling KF, Silverstein NJ, Tanner AS, Eryilmaz H, Smoller JW, Roffman JL.

Nutrients. 2017 Sep 8;9(9):994. doi: 10.3390/nu9090994.

PMID: 28885600

Neural determinants of human goal-directed vs. habitual action control and their relation to trait motivation.

Eryilmaz H, Rodriguez-Thompson A, Tanner AS, Giegold M, Huntington FC, Roffman JL.

Sci Rep. 2017 Jul 20;7(1):6002. doi: 10.1038/s41598-017-06284-y.

PMID: 28729647

Progression from selective to general involvement of hippocampal subfields in schizophrenia.

Ho NF, Iglesias JE, Sum MY, Kuswanto CN, Sitoh YY, De Souza J, Hong Z, Fischl B, Roffman JL, Zhou J, Sim K, Holt DJ.

Mol Psychiatry. 2017 Jan;22(1):142-152. doi: 10.1038/mp.2016.4. Epub 2016 Feb 23.

PMID: 26903271

2016

Multidimensional heritability analysis of neuroanatomical shape.

Ge T, Reuter M, Winkler AM, Holmes AJ, Lee PH, Tirrell LS, Roffman JL, Buckner RL, Smoller JW, Sabuncu MR.

Nat Commun. 2016 Nov 15;7:13291. doi: 10.1038/ncomms13291.

PMID: 27845344

Dopamine D1 signaling organizes network dynamics underlying working memory.

Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C.

Sci Adv. 2016 Jun 3;2(6):e1501672. doi: 10.1126/sciadv.1501672. eCollection 2016 Jun.

PMID: 27386561

Disrupted Working Memory Circuitry in Schizophrenia: Disentangling fMRI Markers of Core Pathology vs Other Aspects of Impaired Performance.

Eryilmaz H, Tanner AS, Ho NF, Nitenson AZ, Silverstein NJ, Petruzzi LJ, Goff DC, Manoach DS, Roffman JL.

Neuropsychopharmacology. 2016 Aug;41(9):2411-20. doi: 10.1038/npp.2016.55. Epub 2016 Apr 22.

PMID: 27103065

Individual Differences in Cognitive Control Circuit Anatomy Link Sensation Seeking, Impulsivity, and Substance Use.

Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Buckner RL.

J Neurosci. 2016 Apr 6;36(14):4038-49. doi: 10.1523/JNEUROSCI.3206-15.2016.

PMID: 27053210

Emerging Treatments in Schizophrenia: Highlights from Recent Supplementation and Prevention Trials.

Brown HE, Roffman JL.

Harv Rev Psychiatry. 2016 Mar-Apr;24(2):e1-7. doi: 10.1097/HRP.0000000000000101.

PMID: 26954600

Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.

Walton E, Hass J, Liu J, Roffman JL, Bernardoni F, Roessner V, Kirsch M, Schackert G, Calhoun V, Ehrlich S.

Schizophr Bull. 2016 Mar;42(2):406-14. doi: 10.1093/schbul/sbv074. Epub 2015 Jun 8.

PMID: 26056378

2015

Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures.

Holmes AJ, Hollinshead MO, O'Keefe TM, Petrov VI, Fariello GR, Wald LL, Fischl B, Rosen BR, Mair RW, Roffman JL, Smoller JW, Buckner RL.

Sci Data. 2015 Jul 7;2:150031. doi: 10.1038/sdata.2015.31. eCollection 2015.

PMID: 26175908

Massively expedited genome-wide heritability analysis (MEGHA).

Ge T, Nichols TE, Lee PH, Holmes AJ, Roffman JL, Buckner RL, Sabuncu MR, Smoller JW.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2479-84. doi: 10.1073/pnas.1415603112. Epub 2015 Feb 9.

PMID: 25675487

2014

Neural predictors of successful brief psychodynamic psychotherapy for persistent depression.

Roffman JL, Witte JM, Tanner AS, Ghaznavi S, Abernethy RS, Crain LD, Giulino PU, Lable I, Levy RA, Dougherty DD, Evans KC, Fava M.

Psychother Psychosom. 2014;83(6):364-70. doi: 10.1159/000364906. Epub 2014 Oct 16.

PMID: 25323387

Dissociable genetic contributions to error processing: a multimodal neuroimaging study.

Agam Y, Vangel M, Roffman JL, Gallagher PJ, Chaponis J, Haddad S, Goff DC, Greenberg JL, Wilhelm S, Smoller JW, Manoach DS.

PLoS One. 2014 Jul 10;9(7):e101784. doi: 10.1371/journal.pone.0101784. eCollection 2014.

PMID: 25010186

Vitamin supplementation in the treatment of schizophrenia.

Brown HE, Roffman JL.

CNS Drugs. 2014 Jul;28(7):611-22. doi: 10.1007/s40263-014-0172-4.

PMID: 24846474

Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.

Pearson-Fuhrhop KM, Dunn EC, Mortero S, Devan WJ, Falcone GJ, Lee P, Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Rosand J, Cramer SC.

PLoS One. 2014 May 16;9(5):e93772. doi: 10.1371/journal.pone.0093772. eCollection 2014.

PMID: 24834916

The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function.

Smoller JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S, Block SR, Weill S, Young S, Choi EY, Rosenbaum JF, Biederman J, Faraone SV, Roffman JL, Manfro GG, Blaya C, Hirshfeld-Becker DR, Stein MB, Van Ameringen M, Tolin DF, Otto MW, Pollack MH, Simon NM, Buckner RL, Ongür D, Cohen BM.

Biol Psychiatry. 2014 Dec 1;76(11):902-10. doi: 10.1016/j.biopsych.2013.12.018. Epub 2014 Jan 18.

PMID: 24529281

2013

Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia.

Roffman JL, Lamberti JS, Achtyes E, Macklin EA, Galendez GC, Raeke LH, Silverstein NJ, Smoller JW, Hill M, Goff DC.

JAMA Psychiatry. 2013 May;70(5):481-9. doi: 10.1001/jamapsychiatry.2013.900.

PMID: 23467813

In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise.

Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL.

Mol Psychiatry. 2013 Apr;18(4):404-16. doi: 10.1038/mp.2013.8. Epub 2013 Feb 26.

PMID: 23439487

Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.

Roffman JL, Brohawn DG, Nitenson AZ, Macklin EA, Smoller JW, Goff DC.

Schizophr Bull. 2013 Mar;39(2):330-8. doi: 10.1093/schbul/sbr150. Epub 2011 Oct 20.

PMID: 22021659

2012

Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.

Holmes AJ, Lee PH, Hollinshead MO, Bakst L, Roffman JL, Smoller JW, Buckner RL.

J Neurosci. 2012 Dec 12;32(50):18087-100. doi: 10.1523/JNEUROSCI.2531-12.2012.

PMID: 23238724

Smoking, but not malnutrition, influences promoter-specific DNA methylation of the proopiomelanocortin gene in patients with and without anorexia nervosa.

Ehrlich S, Walton E, Roffman JL, Weiss D, Puls I, Doehler N, Burghardt R, Lehmkuhl U, Hillemacher T, Muschler M, Frieling H.

Can J Psychiatry. 2012 Mar;57(3):168-76. doi: 10.1177/070674371205700306.

PMID: 22398003

2011

A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.

Roffman JL, Nitenson AZ, Agam Y, Isom M, Friedman JS, Dyckman KA, Brohawn DG, Smoller JW, Goff DC, Manoach DS.

PLoS One. 2011;6(9):e25253. doi: 10.1371/journal.pone.0025253. Epub 2011 Sep 28.

PMID: 21980405

The organization of the human cerebral cortex estimated by intrinsic functional connectivity.

Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL.

J Neurophysiol. 2011 Sep;106(3):1125-65. doi: 10.1152/jn.00338.2011. Epub 2011 Jun 8.

PMID: 21653723